Executive dysfunction in abstinent MDMA (Ecstasy) users

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Executive function in abstinent MDMA ('ecstasy') users.

BACKGROUND Methylenedioxymethamphetamine (MDMA, or 'Ecstasy') is a growingly popular recreational drug of abuse that is known to damage brain serotonergic neurons in animals and possibly humans. Few functional consequences of MDMA-induced serotonin neurotoxicity have been identified, either in animals or humans. This study sought to determine whether individuals with a history of MDMA use showe...

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Jones in recent and abstinent ecstasy / MDMA users

Ecstasy/MDMA use has been associated with various memory deficits. This study assessed declarative and procedural memory in ecstasy/MDMA users. Participants were tested in two sessions, 24 h apart, so that the memory consolidation function of sleep on both types of memory could also be assessed. Groups were: drug-naive controls (n1⁄4 24); recent ecstasy/MDMA users, who had taken ecstasy/MDMA 2–...

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Memory impairment in abstinent MDMA ("Ecstasy") users: a longitudinal investigation.

To examine the neurotoxic potential of continued MDMA ("Ecstasy") use in humans and its functional consequences over the course of 1 year, 15 MDMA users participated in a longitudinal study in which they completed a brief neuropsychological test battery composed mainly of retrospective and prospective memory tasks. Subjects were abstinent for 2 weeks on initial and 1-year testing. Continued use...

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Executive working memory deficits in abstinent ecstasy/MDMA users: a critical review.

AIMS This review examined studies of executive functioning in abstinent ecstasy (3,4-methylenedioxymethamphetamine, MDMA) users on tasks which had been empirically mapped onto updating, shifting, inhibition and accessing long-term memory executive processes. Studies of some aspects of visuospatial memory performance were also included because of the investment of executive resources in such tas...

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3,4-Methylenedioxymethamphetamine (MDMA or ecstasy) is a popular recreational drug that has been shown to induce loss of brain serotonin (5-HT) neurons. The purpose of this study was to determine the usefulness of pharmacological magnetic resonance imaging (phMRI) in assessing 5-HT dysfunction by examining the hemodynamic response evoked by infusion with the selective 5-HT reuptake inhibitor ci...

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ژورنال

عنوان ژورنال: Archives of Clinical Neuropsychology

سال: 2000

ISSN: 0887-6177,1873-5843

DOI: 10.1093/arclin/15.8.756